抄録
Currently, lipid-based particles are mostly used for controlled release of drugs and drug targeting. The introduction of polyethylene glycol (PEG) derivative to lipids, i.e. “PEGylated” makes long-circulating liposomes in blood. Furthermore, PEGylation has emerged as a platform for incorporation of active targeting ligands, providing the drug and gene carriers with specific targeting properties through a flexible tether. This review focuses on the developments surrounding such functional PEGylation of lipid-based particles to promote tissues and cell-targeting, thereby enhancing efficacy of therapeutic strategies.
