Protein Purification Using Anion–Exchange Hollow–Fiber Membrane

Abstract

It is widely recognized that membrane adsorbers are powerful tools for the purification of biopharmaceutical pro-tein products and for this reason a novel hollow–fiber AEX type membrane adsorber has been developed. The mem-brane is characterized by grafted chains including DEA ligands affixed to the pore surfaces of the membrane. Whenchallenged with a solution containing protein, the membrane has high impurity removal further indicating this hol-low–fiber based membrane adsorber is an effective tool for purification of biopharmaceutical protein products includ-ing IgG.