Extracellular Vesicles (EVs) such as exosomes are nanovesicles secreated by various types of cells. There is considerable interest in the use of exosomes as potential drug delivery system (DDS). We propose new strategies for applications of exosomes to DDS by modification of the surface of exosomes with functional polymers such as nanogels or by hybrid with liposomes. Functional nanogel/exosome and liposome/exosome hybrids offer a new option of wide utilization of exosomes in nanomedicine. Exosome delivery of CagA as major virulence factor of Helicobacter pylori and functions of cytotoxic T cell–derived in cancer are also discussed.
