抄録
The pleura which is membrane is covering of thoracic cavity. A defect or injury of visceral pleura causes air leakage from lung parenchyma, the presence of air in the thoracic cavity lead to lung collapse. Several methods including the use of various sealants are ineffective in the closure of air leaks (ALs), and various surgical techniques result in pleural adhesion which is negative consequences. We previously reported a novel method of cell–sheet engineering of lung AL sealants using cell sheets harvested from temperature–responsive culture dishes. Tissue engineered cell sheets is closing ALs, respond according to the dynamic movements of the lungs during respiration, and avoids pleural adhesion. Additionally, host mesothelial cells migrate to cover the transplanted cells sheets. Therefore, tissue engineered cell sheets are expected to become new material for therapy of pleural defect or injury.
