高分子支持膜上でのアミロイド形成

抄録

Substrate supported polymer membranes are promising materials as well as substrate supported lipid bilayers as a platform for medical devices and biosensors. The property of substrate supported polymer membranes depends on the preparation method and the entanglement of the polymers in the membrane. The amyloid fibril formation of amyloid βprotein and its accumulated property was investigated. Fibril formation depends on the kinds of polymers, and their molecular weight. These results suggests the contribution of entanglement in membranes and hydration properties to the fibrillogenesis. Thus, substrate supported polymer membranes can be expected as a biological membrane system.