Abstract
Urate and vitamin C (VC) are closely related to our health problem. Therefore, it is clinically important to maintain blood urate and VC levels in appropriate ranges. Since both compounds are lipophobic, membrane transporters are necessary to regulate their behavior in our body. As urate transporters, urate transporter 1 and glucose transporter 9 play pivotal roles in the reabsorption of urate from urine. In addition, ATP–binding cassette transporter G2 is a crucial transporter in urate excretion at the small intestine. As VC transporters, sodium–dependent VC transporter 1 and 2 participate in VC uptake into cells in several tissues. However, only by these already–identified transporters, we cannot describe the whole pictures of urate and VC homeostasis. Hence, researchers make great efforts to search for novel transporters that have physiological functions in our body.
