ミニレビュー
国内デング熱の臨床―当院での診療経験を交えて―
2015 年 66 巻 4 号 p. 207-209
詳細
2015 年 66 巻 4 号 p. 207-209
Autochthonous dengue fever was recently reported in Japan for the first time in about 70 years. We report autochthonous dengue fever in 19 patients who presented to the National Center for Global Health and Medicine in Tokyo, Japan during August 26, 2014–September 22, 2014. Fifteen of these patients had recently visited Yoyogi Park, Shibuya-ku, Tokyo, and the remaining 4 patients had visited other public places in Tokyo. The dengue virus genome was detected from the serum of 18 patients, and the serotype in all was dengue virus serotype-1 (DENV-1). Phylogenetic analysis of the DENV E-protein genome sequence obtained from the serum sample of 3 patients revealed that these sequences had 100% identity to the sequence of a DENV strain of the first diagnosed case in Japan. The DENV-1 strain possessed a high degree of homology with the sequence of a DENV strain isolated from China in 2013 and Indonesia in 2010.
