Development Toward to Industrialization of Functional Cosmetics and Medical Devices Based on PLGA Nano Particulate Design and Preparation

Abstract

Drug-loaded PLGA nanospheres prepared using the emulsion solvent diffusion (ESD) method developed by Kawashimaʼs group could be applied further to not only pharmaceuticals, including tablets, injection, topical creams, powder inhalation (DPI) but also cosmetic delivery system and medical devices such as stents and balloon catheters based on our DDS platforms that was established by cooperation with academia, industry and government team under the funding by NEDO.

We have firstly launched a new hair restorations named “NanoImpact (2006),” involving several crude drugs loaded into PLGA nanospheres as well as functional skin-care cosmetic “Nano Crysphere (2004),” which has pro-vitamin C-loaded PLGA nanospheres etc. A nano- drug-delivery system (DDS) using PLGA nanosphere system cooperated is going on their clinical trials.

This paper briefly describes those PLGA nanosphere technologies.