Special Subject: Powder Technology to Create a Prosperous Future
The Cancer Treatment Strategy with the Inorganic/Bio-Complex Nanoparticle
2017 Volume 60 Pages 13-19
Details
2017 Volume 60 Pages 13-19
A bio-nanocapsule (BNC) that is composed of the L protein of the hepatitis B virus (HBV) surface antigen and a lipid bilayer shows high specificity for human hepatocytes. Therefore, we have developed various specificity-altered BNCs for cancer cell types by gene engineering. While at the same time, we have demonstrated that titanium peroxide nanoparticle (TiOx) shows anticancer effect in combination with X-ray irradiation. Therefore, we tried to encapsulate the TiOx in the BNC and deliver this complex particle into the target tumor. As a result, we succeeded in demonstrating antitumor effect against mouse xenograft model with a combination of the complex particle and X-ray irradiation.
