Special Subject: Powder Technology Required for Creation of Advanced Materials
Smart Particle Design for Advanced Functional Formulations~Creation and Evaluation of Opusgran®~
2018 Volume 61 Pages 28-34
Details
2018 Volume 61 Pages 28-34
In the design of the functional particles, we have been required the technology to prepare the high drug loading fine spherical particles, which has not been established yet. We have studied a solution to the above problem, and succeeded in creating a high-loading spherical granules (Opusgran®) by high-speed stirring granulation and novel idea. Also, we found that this granule has a hollow structure. The success of the production of Opusgran® granules does not depend on the solubility and any characteristics of the drug. And it does not depend on any functions and the particle size of the polymer, either. Opusgran® granules can be produced from all of the drug substance and all of the polymer. The primary advantage of Opusgran® is that it can impart a function of the polymer used for the granules. For example, we obtained the high-loading fine spherical granules of poorly soluble compound with release controlled for more than 24 hours by sustained release polymer. In addition, we can easily obtain functional tablets without losing the function of Opusgran® by tableting. So, in the future, we will be able to produce almost all solid dosage forms with various functions by only this Opusgran® technology.
