New Evidence of Hair Growth with PLGA Nano-Sphere Technology

Abstract

The “Nano DDS-type hair-growth agent with PLGA nanospheres” is our core technology and has a high hair-growth effect, and has been actually used for hair growth in humans. In this report, we present the results of an in vitro test using dermal papilla cells, which play a central role in the normalization of the hair cycle, which is essential for hair growth, and in the formation and growth of hair follicles. In experiments using cells, we evaluated cell activating effects, gene expression of hair growth-promoting factors, and expression-suppressing effects of genes related to hair loss. The results showed that PLGA NS, which contains hair-growth components, has effects on the activation of papilla cells, normalization of the hair cycle, promotion of hair follicle formation, promotion of blood flow, and prevention of telogen effluvium transition (hair loss). These effects indicate that PLGA NS is an extremely useful delivery technology that allows hair-growth ingredients to penetrate deep into the pores and remain at the site of action for a sustained effect.