Digital imaging is now being introduced in pathology, owing to the recent advancement of whole slide imaging, or digital slide technology. In this paper, after the review of the significance of digital imaging in pathology, a fully-automatic image analysis system developed aiming at quantitative pathology is introduced. Then an important problem in pathology image analysis, the color management is addressed, including the international activity on that issue. The application of multispectral technology to pathology is also presented. The digital image analysis technology will change the pathology diagnosis from qualitative or semi-quantitative to quantitative, and it is expected to bring considerable impact to the cancer diagnosis and treatment.