Magnetic Resonance in Medical Sciences
Online ISSN : 1880-2206
Print ISSN : 1347-3182
ISSN-L : 1347-3182
Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord
Masaaki HoriTomoko MaekawaKouhei KamiyaAkifumi HagiwaraMasami GotoMariko Yoshida TakemuraShohei FujitaChristina AndicaKoji KamagataJulien Cohen-AdadShigeki Aoki
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2022 Volume 21 Issue 1 Pages 58-70


Diffusion tensor imaging (DTI) has been established its usefulness in evaluating normal-appearing white matter (NAWM) and other lesions that are difficult to evaluate with routine clinical MRI in the evaluation of the brain and spinal cord lesions in multiple sclerosis (MS), a demyelinating disease. With the recent advances in the software and hardware of MRI systems, increasingly complex and sophisticated MRI and analysis methods, such as q-space imaging, diffusional kurtosis imaging, neurite orientation dispersion and density imaging, white matter tract integrity, and multiple diffusion encoding, referred to as advanced diffusion MRI, have been proposed. These are capable of capturing in vivo microstructural changes in the brain and spinal cord in normal and pathological states in greater detail than DTI.

This paper reviews the current status of recent advanced diffusion MRI for assessing MS in vivo as part of an issue celebrating two decades of magnetic resonance in medical sciences (MRMS), an official journal of the Japanese Society of Magnetic Resonance in Medicine.

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© 2022 by Japanese Society for Magnetic Resonance in Medicine

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