Diffusion Tensor Imaging in Familial Spastic Paraplegia with Mental Impairment and Thin Corpus Callosum

Miho OTA; Noriko SATO; Yuji SAITOH; Fumito ENDO; Miho MURATA; Takashi ASADA

doi:10.2463/mrms.7.163

Case Report

Diffusion Tensor Imaging in Familial Spastic Paraplegia with Mental Impairment and Thin Corpus Callosum

Miho OTA, Noriko SATO, Yuji SAITOH, Fumito ENDO, Miho MURATA, Takashi ASADA

著者情報

キーワード: diffusion tensor imaging, familial spastic paraplegia, fractional anisotropy, mean diffusivity

ジャーナルオープンアクセス

2008 年 7 巻 3 号 p. 163-167

DOI https://doi.org/10.2463/mrms.7.163

詳細

抄録

We investigated 2 Japanese siblings with a complicated form of familial spastic paraplegia. Cranial magnetic resonance (MR) imaging revealed marked thinning of the corpus callosum. Diffusion tensor imaging (DTI) showed microstructural changes in the thalamus, basal ganglia, and cerebral white matter, and single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer showed very similar findings. DTI and SPECT effectively revealed global changes not revealed by conventional MR imaging.

責任著者(Corresponding author)

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