Two new furanone glycosides, malfilamentosides A and B, from Malbranchea filamentosa

Abstract

In the course of searching for new antifungal substances in Malbranchea spp., two new furanone glycosides, malfilamentosides A (1) and B (2), were isolated from Malbranchea filamentosa along with a furanone derivative, 4-benzyl-3-phenyl-5H-furan-2-one (3) and a dioxopiperazine derivative, amauromine, and an anthraquinone, erythroglaucine. The structures of 1 and 2 were established by spectroscopic and chemical investigation. Malfilamentosides A (1) and B (2) are the first examples of the glycosides of the furanone derivative from the fungal sources.