Abstract
Duclauxin and related compounds were examined for cytotoxicities on murine leukemia L1210 culture cells and inhibitory effects on mitochondrial respiration. The potencies in cytotoxicity and inhibitory effect of duclauxin were markedly decreased when the oxygen atom of isocoumarin nucleus was substituted by nitrogen but were not significantly decreased when the oxygen atom was substituted by tertiary amines to produce N-methyl and Nethyl-duclauxamides, showing a good correlation between cytotoxicity on L1210 culture cell and inhibitory effect on mitochondrial respiration.
