Acute toxicities of satratoxins G and H in mice-a histopathological observation with special reference to the liver injury caused by satratoxin G

Abstract

To assess toxic effects of the purified satratoxins G and H, 4 week-old ddY male mice were given a single intraperitoneal injection and were evaluated for histopathological evidence of the organ injuries. Intraperitoneal LD₅₀ of satratoxins G and H were estimated as 1.23±0.08 and 5.69±0.43mg/kg body weight, respectively. Both toxins caused extensive ulceration of the small intestine and a relatively mild damage of the lymphoid and hematopoietic tissues in lethal animals. Furthermore, satratoxin G caused vacuolar and fatty degeneration of the hepatic cells.