Abstract
The 50% lethal doses (LD50, mg/kg) of nivalenol (NIV), one of the trichothecene mycotoxins produced by Fusarium species, in 6-week-old male ddY mice were determined as 38.9 (po), 7.4 (ip), 7.16 (sc) and 7.3 (iv). The minimum effective doses (μg/spot) for dermal toxicity in 6-week-old male Sprague-Dawley rats were 0.02 (T-2 toxin, T-2), 1.0 (NIV) and 2.0 (deoxynivalenol, DON). The relative cytotoxicity of 50% survival concentration (μg/ml) in the H4-II-E (Reuber rat hepatoma cell), 3Y-1 (Fischer rat embryofibroblast), Rous sarcoma virus-transformed 3Y-1 and Kagura-1 (aflatoxin B1-induced rat hepatoma cell) was 50-300 times on T-2 and 2-6 times on NIV in comparison to DON as 1.
