腎機能障害に對する肝臟の利用 第2篇

肝臟の電解質排除に關する動物實驗

抄録

Fifty normal rabbits were determined for the serum and the bile. The concentration of electrolytes was slightly lower in the rabbit serum and bile than in the human serum and bile, and, in rabbits, the serum was a little more abundant in electrolytes than was the bile.
The outflow of bile was observed on the rabbits which were nephrectomized and subjected 24 hours or shortly thereafter to artificial bile fistula, by introducing glass canules into their common ductus.
The outflow and the electrolyt excretion in bile were larger in amount 24 hours after nephrectomy than immediately subsequent to it, being in the former almost two-fold as much as in the latter. The tendency was enhanced by the intravenous injection of Sodium dehydrocholate.
Sodium dehydrocholate increased the excretion of chloride in the bile two-fold as much as befor it was given, although it lowered the chloride concentration in bile rapidly. As for the sodium, it entailed the increase in excretion without decrease in concentration. Repeated injection of sodium dehydrocholate was thought to be necessary for the complete compensation of liver for the lost function of kidneys, but its reinjection was unfortunately almost ineffective. However, the reinjection restored its effectiveness after rabbit bile had been introduced into the intestine.
But reinjection remained ineffective when glucose and physiological saline were used instead of bile.
Chloride concentration in bile commenced to rise one hour after the introduction of saline into the intestinal canal and ascended increasingly with the lapse of time for six hours. This seems to provide support for the hypothesis of enterohepatic circulation postulated by Rzentokowski.
Similar effect was obtained when rabbit bile was used, presumably because of the chloride which was contained in it.