内科疾患における血液ビタミンB₁₂について

抄録

After surveying various internal diseases, especially blood diseases, the following results were obtained concerning Vitamin B₁₂ concentration in 1 ml of the whole blood and serum observed during the process of these diseases.
(1) The Vitamin B₁₂ concentration in 1 ml of the whole blood shows higher value than that in 1 ml of the serum.
(2) The average value of Vitamin B₁₂ concentration in the whole blood of patients with aplastic anemia is about twice the normal. The administration of folic acid or cortisone, in this disease, has no effect on Vitamin B₁₂ concentration in the whole blood.
(3) Vitamin B₁₂ concentration is somewhat increased in case of acute type of myeloic leukemia, but the concentration is markedly increased in case of its chronic type.
In case of chronic myeloic leukemia, it seems that there is correlation to some extent between the white blood cell count and Vitamin B₁₂ concentration in the whole blood, though not absolute. The Vitamin B₁₂ concentration in the whole blood of erythremia patient is also increased.
(4) In liver diseases, specifically in cirrhosis of the liver, infectious hepatitis, serum hepatitis and in tumor of the liver there are an increase of Vitamin B₁₂ concentration of the whole blood, though the number of cases were relatively few. Contrary, in each case of liver abscess and cholecystitis, Vitamin B₁₂ concentration in the whole blood was within normal limit.
(5) In case of iron deficiency anemia, Vitamin B₁₂ concentration in the whole blood was within normal limit.
(6) In case of thrombocytopenic purpura, Banti's syndrome, benzol-poisoning, hemolytic anemia, cancer of the stomach and in chronic nephritis, Vitamin B₁₂ concentration in the whole blood was within normal limit.