1955 年 44 巻 9 号 p. 936-943
For the purpose of elucidating the relation between serum Ca and vitamin B1 in the body, the Ca content in serum of rabbits was reduced by inducing persistent hyper-or hypoglycemia or administering oxalic acid or acetic acid. Their subsequent total serum Ca, serum dialytic Ca, the drop number, the blood VB1 content and the excretion of VB1 in urine were measured. The serum Ca content and the VB1 content in the body in some diseases and pregnancy were also determined. Furthermore Ca was administered to subjects suffering from Ca deficiency in serum or VB1 deficiency and the subsequent VB1 metabo lism was followed up. The results obtained were as follows:
1) Adiminution of serum Ca disturbs the metabolism of VB1 in the body. Such a reduction of serum Ca content heightens the consumption of bodily VB1 on the one hand, and on the other lowers the utilization of the vitamin in the body.
2) This disturbance of VB1 metabolism caused by a diminition of serum Ca may be prevented or cured by administration of Ca An oral administration is more effective than otherwise.
3) Administration of VB1 is effective in preventing the reduction of serum Ca content and causes its slight rise. Therefore, it may be concluded that the Ca content in serum and the VB1 content in the body stand in mutual correlation.