不飽和七員環化合物の實驗的並びに臨床的研究

第29報 Hinokitiol, Tropolone 及び若干誘導体のCandida屬眞菌に對する試驗管内抗黴作用

抄録

The author examined the antifungal activity of 6 unsaturated seven-membered ring compounds on 8 species of candida: C. albicans YU 1200, C. albicans 406 MGL 3rd AAL Duke university, C. krusei, C. parakrusei, C. tropicalis, C. pseudotropicalis and C. stella-toidea 264 Haverd university.
The author used Czapek's modified medium from which FeSO₄·7H₂O was excluded.
The results were as follows:
The minimum inhibitory concentration of hinokitiol was 1-10mcg/ml on 8 species of candida. It was 2.5-25mcg/ml for hinokitiol-natrium and also for tropolone.
The mean minimum inhibitory concentration of hinokitiol was 3.9 mcg/ml against 8 strains of candida. It was 7.2mcg/ml for hinokitiol-natrium and 9.1 mcg/ml for tropolone. Therefore, it has been proved that hinokitiol, hinokitiol-natrium and tropolone have a strong inhibitory action against fungi of genus candida.
On the other hand, hinokitiol ammonium sulfonate, 3·5-dibromotropolone and 3·5·7-tribromotropolone did not show the growth inhibitory effects on them in the concentration of 100 mcg/ml.
As a control, the author experimented the antifungal effect of trichomycin and nystatin against them.
The minimum inhibitory concentration of trichomycin was 0.5-5mcg/ml and it was 2.5-25mcg/ml for nystatin. The mean minimum inhibitory concentration of trichomycin was 2.5mcg/ml and it was 9.4 mcg/ml for nystatin.
Accordingly, it was confirmed that the antifungal activities of hinkitiol, hinokitiol-natrium and tropolone were almost the same as trichomycin or nystatin on 8 species of candida.