Expression of Calmodulin and FNDC5 Reverses with Increasing Radiation Dose, Altering Cell Invasion on Pancreatic Cancer Cells

Abstract

Pancreatic cancer (PC) is a highly mortal disease and one of the most malignant gastrointestinal tumors. Our previous studies have demonstrated that phosphorylation of eIF2a, which occurs during endoplasmic reticulum stress, suppresses cell invasive capacity. However, the relationship between radiation-induced ER stress and cell invasion is not well understood. Therefore, in this study, we evaluated the effect of combining irisin with radiation therapy on apoptosis and metastasis of pancreatic cancer cells, and in this study, we also investigated the mechanism of the effect of irisin and radiation therapy on pancreatic cancer cells, and we hope that this approach may improve the survival rate of pancreatic cancer. Our data suggest that the combination of irisin and radiation therapy can inhibit the migration and invasion of pancreatic cancer cells through inhibition of calmodulin (CaM), and identified the Ca²⁺- CaM signaling pathway, which may play a key role in the induction of irisin and radiation therapy in role in the era where malignant tumors have entered the era of individual therapy and the expression status of specific targets has become the patient's chemotherapy regimen, which also allows the combination of irisin and radiation therapy to provide new ideas for the treatment of pancreatic cancer.