Abstract
Needless to say, pediatric cancer therapy, especially leukemia, had remarkably progressed and successful changed in last century. However, the chemo-radiation therapy of diffuse intrinsic pontine glioma (DIPG) has still been behind the success story of pediatric cancer therapy. Although, neurosurgical pioneers had tried a lot of new project to cure pediatric DPIG, nothing of new effective protocols have been accepted with satisfactory long term survival. So, we review the pediatric DIPG therapies of neurosurgical pioneers, reconsider temozolomide based protocol, discuss to need brain biopsy, and look for the new direction of pediatric DIPG in the near future.
