シンコニジン修飾白金-炭素触媒によるベンゾイルギ酸エチルの不斉水素化-触媒調製法と不斉収率との関係-

抄録

The hydrogenation of ethyl benzoylformate over the platinum carbon (Pt/C) catalyst modified. with cinchonidine gave (RH)-(-)-ethyl mandelate in an optical yield of 89.5%. The asymmetric hydrogenation activity of the catalyst was strongly affected by preparation of the Pt/C catalyst. The best Pt/C catalyst was obtained by the following procedures; 1) reduction of H₂PtCl₆⋅6H₂O/ active carbon with sodium formate, 2) treatment of the resulting Pt/ C catalyst with acetic acid, and 3) preheating of the Pt/C catalyst at 300-400°C in hydrogen immediately before its modification with cinchonidine.