ジペプチド基を有するポリマーによる光学活性なエステル類の立体選択的加水分解金属イオンの添加効果

抄録

Stereoselective hydrolysis of amino acid p-nitrophenyl esters was examined for poly (ethylenimine) derivatives with covalently-linked dipeptide containing a histidyl residue in the presence of copper(II) ions. Added copper(II) ions influenced both the rate constant and the ratio of stereoselectivity in the hydrolysis of the chiral esters by poly(ethylenimine)derivatives (I_a and I_b) depending on the nature of the esters and the modified polymers. Added copper(II) ions caused to increase the rate of the reaction, but no significant effect on the stereoselective preference for the quaternized polymer (I_b), indicating the action of copper(II) ions in the hydrolysis of the esters as catalyzed by a histidyl residue on the polymer.