抄録
Objective: Calcium redistribution is closely associated with atherosclerotic risk factors and the cardiovascular system.
Methods: The subjects were 71 men and 59 women who underwent health screening at our hospital. After measuring bone mineral density (BMD) and pulse wave velocity (PWV), echocardiography and chest computed tomography (CT) were performed. The relationships among thoracic arterial calcification (TAC), BMD, and atherosclerotic risk factor parameters or cardiovascular system parameters were investigated.
Results: TAC and BMD were not correlated, nor was there a significant difference in BMD between the severe and mild TAC groups. Age, HbA1c (JDS), pulse pressure (PP), PWV and E/A ratio were significantly higher in both men and women in the severe TAC group. TAC was significantly correlated with age, PP, PWV, and E/A in both men and women. The body mass index (BMI) was significantly lower in men in the low BMD group, and the age of the women was significantly higher. Regarding correlations between atherosclerotic risk factor parameters and cardiovascular system parameters and BMD, HbA1c and relative wall thickness were significantly correlated with BMD in men, and age, BMI, and E/A were significantly correlated with BMD in women.
Conclusion: TAC was associated with both arterial stiffness and cardiac function, while BMD was mainly associated with cardiac remodeling. Cardiovascular system parameters were strongly correlated with age and atherosclerotic risk factors, suggesting that an improvement in atherosclerotic risk factors and countermeasures against osteoporosis may prevent remodeling of the cardiovascular system through calcium redistribution.
