抄録
Background and Methods To clarify the factors which influence B-type natriuretic peptide (BNP) concentration in healthy individuals,559 individuals (267 men and 292 women) were examined for their BNP levels and other indices.
Results The BNP concentrations were significantly higher in female than male counterparts and increased with increasing age. The maximum difference of mean BNP concentration was observed in females in their 60s and males in their 30s (25.2 mg/dl,7.1 mg/dl respectively), the difference was more than 3.5times. Positive relations were observed in age, systolic BP, pulse pressure and augmentation index (Al); negative relations were observed in immunoreactive insulin (IRI), γ-GTP, albumin, Hb, hematocrit, RBC, uric acid and heart rate. The most significant correlation with serum BNP level was observed in Hb (r=0.329). There was a statistical significance in mean overall serum BNP level between the obesity and normal weight groups (p=0.009). The difference of mean BNP concentration between smoker and nonsmoker groups was not statistically significant but smokers tended to have lower BNP concentrations than nonsmokers.
Conclusion These differences were considered to be caused by the subsequent secondary erythrocytosis in obesity and smoking. Further studies of BNP change in various situations are needed to clarify the mechanism inducing cardiac stress.
