2022 年 9 巻 1 号 p. 47-53
Objective: To investigate the clinicopathological characteristics of superficial non-ampullary duodenal epithelial tumors (SNADETs) detected during endoscopic gastric cancer screening and to determine their association with gastric mucosal atrophy.
Methods: Twelve patients diagnosed as having SNADETs during the 6-year period from April 2015 to March 2021 were included in the study. Data on tumor localization, size, macroscopic type, presence or absence of milk-white mucosa, treatment, and histology were analyzed. The degree of endoscopic gastric mucosal atrophy was compared between patients with SNADETs and 60 sex- and age-matched controls.
Results: SNADETs were found in the second part of the duodenum in all patients. The most common macroscopic type was 0–IIa (8 lesions, 61.5%). Milk-white mucosa was found in 12 lesions (92.3%), and its distribution pattern correlated with the histological type. The frequency of open-type gastric mucosal atrophy and the gastric mucosal atrophy scores were lower in the SNADET group than in the control group, but the difference was not significant.
Conclusions: Gastric cancer screening performed as part of the Comprehensive Health Checkup System should include an assessment of the second part of the duodenum. SNADETs tend to occur against a background of non-atrophic gastric mucosa; therefore, if milk-white mucosa is observed during screening, the possibility of SNADETs should be considered.
