Calf Thymus Chromatin Digestion by Epidermal Acid DNase and Protease Activity for Histone (Chromatin) in Epidermal Extract

Abstract

An acid DNase of guinea pig epidermis hydrolyzes chromatin DNA as well as histone-free DNA. The enzyme degrades approximately 50% of chromatin DNA, while it degrades approximately 90% of histone-free DNA. Guinea pig epidermal extract contains proteolytic activity for histone or chromatin with a pH optima at around 8.0.