Biological Properties of Herpes Simplex Virus Type 2 Isolated from the Recurrent Facial Lesions of an Infant

Abstract

Five isolates of herpes simplex virus (HSV) were recovered at different times over a two year period from recurrent herpetic lesions of the face of an infant. In order to investigate whether the recurrent lesions were induced by viruses with the same or different biological properties, five isolates were studied in tissue culture, in animals, and serologically. The findings were as follows;
1) All isolates were HSV type 2.
2) No significant differences were observed in these five isolates as determined by plaque size on chick embryo fibroblasts, pock size and neurovirulence in mice.
3) Antigenic differences were not detected in these five isolates by neutralization tests.