Abstract
A 39-year-old woman had been diagnosed as a case of systemic lupus erythematosus (SLE) 7 years before her final admission because of liver dysfunction. Generalized erythema and multiforme-like eruptions appeared after treatment with Thiola. The exanthema was similar to toxic epidermal necrolysis (TEN). Soon after initiating treatment of the TEN type drug eruption, by an oral corticosteroid, generalized convulsion and semicoma occurred. Because central nervous system involvement was suspected, the dose of corticosteroid was increased. The neurologic symptoms gradually subsided during one month. She was discharged and the dose of corticosteroid was gradually decreased.
