The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 48, Issue 2
Displaying 1-27 of 27 articles from this issue
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Color Atlas
Mini Review
Clinical Case Reports
  • A Case of Epidermolysis Bullosa Herpetiformis Dowling-Meara
    Tatsuya MIYAOKA, Yutaka YASHIMA, Shuhei IMAYAMA
    1986 Volume 48 Issue 2 Pages 222-227
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.222
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    We treated a 22-year-old woman with epidermolysis bullosa herpetiformis Dowling & Meara. Blistering started on the hands and feet at the age of a few months and the blister formation was exacerbated to the extent of trunk and extremity involvement at the age of 19. In the summer seasons, half-rice to pea sized vesicles associated with severe itching occurred frequently. Each vesicle healed within a few days and spread peripherally, thus the lesions exhibited circinate patterns. On healing, they left no scarring other than pigmentation. Neither milia nor nail dystrophy was evident. There was no evidence of similar conditions among relatives. Ultrastructural studies of the fresh vesicles demonstrated a transverse crack in the basal layer, leaving the digitated processes of the basal cells as the floor of the blister.
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  • Eccrine Poro-Ductoma
    Kazuo ASO, Chikako YAMAGUCHI, Shinichi ANZAI, Yutaka HOZUMI
    1986 Volume 48 Issue 2 Pages 228-235
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.228
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    Two cases of eccrine tumor histologically suggesting both eccrine poroma and acrospiroma are reported. The first case was a 70 year old woman with a tumor on the dorsal aspect of the foot and other, an 83 year old woman with a tumor on the left cheek. Electronmicroscopic study of the first case revealed the presence of intracellular lumen, periluminal filamentous zone, lysosomes, keratohyaline granules as well as intracellular lumens surrounded by microvilli. According to the classification of eccrine tumor by Mishima and Morioka, the tumors were considered to be eccrine poroductoma originating from acrosyringium and eccrine ducts in the upper dermis.
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  • A Case of Albright’s Hereditary Osteodystrophy
    Yasuki NII, Atsushi IRIKI, Shuhei IMAYAMA, Masakazu ASAHI
    1986 Volume 48 Issue 2 Pages 236-239
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.236
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    We treated a 3-year-old girl with Albright’s hereditary osteodystrophy. Since birth, she had had erythemas, brownish pigmentation and subcutaneous nodules, several milimeters in diameter, scattered over the trunk and extremities. She also was of short stature, had a round face, and short little finger. Serum calcium and phosphate values were within normal limits but serum parathyroid hormone level was substantially elevated. Microscopic examination of subcutaneous nodules showed ossification of the deermis.
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  • Localized Neurofibroma and Crossed Overlap of Dermatome
    Takahiko TSUNODA, Shun-ichi OGAWA
    1986 Volume 48 Issue 2 Pages 240-243
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.240
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    Localized neurofibroma associated with Bowen’s disease was present on the back of a 78-year-old woman. The family history was unremarkable and a specific manifestation of multiple neurofibromatosis was nil. Neurofibromas began to grow from her age of 60, and 26 tumors were distributed systematically in the area of the left thoracic 9 and 10 dermatomes. Two tumors extended to the right side beyond the midline of the trunk. From previous findings on the distribution of cutaneous nerves of the back (Tsunoda, 1982), we considered that these 2 tumors grew along the cutaneous nerves which crossed over the posterior midline of the trunk from left to right, forming the so-called crossed overlap of dermatome. Bowen’s disease appeared on the lower back 8 years before. The association of the two diseases was probably coincidental.
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  • A Case of Tick-Bite with Ixodes nipponensis
    Chiharu IMAOKA, Joji JIDOI, Tsutomu OHATA, Satoshi DEKIO, Yousuke YAMA ...
    1986 Volume 48 Issue 2 Pages 244-247
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.244
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    A 5-year-old girl had a tick-bite and surgical excision was done. The tick was identified to be Ixodes nipponensis. As a tick can transmit infectious diseases, such as tularemia, the affected site and the general health of the patient were followed. There were no untoward effects. The classification of ticks and epidemiology of tick-transmitted infectious diseases in Japan are discussed.
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  • A Case of Sporotrichosis with Numerous Fungal Elements
    Takako TAKASE, Toru BABA, Kenichi UYENO, Atsuhiko HASEGAWA
    1986 Volume 48 Issue 2 Pages 248-251
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.248
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    A 69-year-old female farmer had an ulcerative lesion on the left forearm and she had not noticed any foregoing trauma at that area. Many fungal elements were seen on biopsy specimens stained with PAS and Sporothrix schenckii was isolated from the specimens. Fungal elements showed polymorphous features such as asteroid body, large or small spores without radiate formation and intracellular spores. However, the most characteristic finding was that relatively large spores were the most frequent. The lesion was cured with potassium iodide and local heat treatment for 3 months.
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  • Psoriatic Arthritis Limited to Nail Psoriasis
    Hitoshi MIZUTANI, Masayuki SHIMIZU
    1986 Volume 48 Issue 2 Pages 252-256
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.252
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    Two cases of psoriatic arthritis are presented. The skin manifestation was limited to the nail lesion without typical psoriasiform eruption elsewhere. Diagnosis of psoriatic arthritis and nail psoriasis mainly depend on the presence of psoriatic skin lesion, thus a correct diagnosis was difficult. Diagnostic value of the relationship between nail psoriasis and psoriatic arthrtis and roentogenographic findings in psoriatic arthritis are discussed.
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  • A Case of Systemic Lupus Erythematosus Complicated with Toxic Epidermal Necrolysis Type Drug Eruption
    Toshitatsu NOGITA, Katsuro OHYAMA, Yoshihiro MAEKAWA
    1986 Volume 48 Issue 2 Pages 257-261
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.257
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    A 39-year-old woman had been diagnosed as a case of systemic lupus erythematosus (SLE) 7 years before her final admission because of liver dysfunction. Generalized erythema and multiforme-like eruptions appeared after treatment with Thiola. The exanthema was similar to toxic epidermal necrolysis (TEN). Soon after initiating treatment of the TEN type drug eruption, by an oral corticosteroid, generalized convulsion and semicoma occurred. Because central nervous system involvement was suspected, the dose of corticosteroid was increased. The neurologic symptoms gradually subsided during one month. She was discharged and the dose of corticosteroid was gradually decreased.
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  • Total Lipodystrophy
    Tetsuo SHUKUWA, Michiko SADAMORI, Katsutaro NISHIMOTO
    1986 Volume 48 Issue 2 Pages 262-266
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.262
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    Acquired total lipodystrophy was diagnosed in a 54-year-old woman. She had a generalized loss of subcutaneous fat tissue which began at the same time as non-insulin-dependent-diabetes mellitus and hyper-lipoproteinemia. Microscopic findings of the subcutaneous fat tissue disclosed atrophy of all the adipose cells.
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Clinical and Investigative Report
  • Clinical Application of Skin Tests in Tinea, Sporotrichosis and Chromomycosis
    Japanese Research Team for the Fungal Skin Test Antigens
    1986 Volume 48 Issue 2 Pages 267-277
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.267
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    Peptide antigens were newly prepared from the mycelia of Trichophyton, Sporothrix and Fonsecaea species. Tuberculin-type skin test were done at 10 dermatology clinics of university hospital in Japan with these antigens, and also with the conventional test antigens, on clinical cases and their clinical usefulness was evaluated.
    1) Peptide antigens from Trichophyton mentagrophytes and T. rubrum gave a positive reaction in 75% of Tinea cases. Specific difference was not proved between these two species.
    2) The conventional trichophytin gave considerable fewer positive reaction (25%).
    3) Intensity of the reactions were greatly different among each case of tinea.
    4) Immediate-type reactions were observed in 85% of the tinea cases.
    5) Intensity of the reaction in Kerion Celsi was almost similar to that of the superficial tineas.
    6) In the tineas due to Microsporum canis, the most intense reaction was noted with M. canis antigen. However, other antigens (T. mentagrophytes and T. rubrum) also gave a positive reaction.
    7) In sporotrichosis, the peptide antigen and the conventional sporotrichin gave almost similar reactions, although several weak responders were noted with the conventional sporotrichin.
    8) Immediate-type skin reaction was also observed in sporotrichosis.
    9) In 5 case of chromomycosis, 3 gave negative and 2 gave weakly positive reaction, suggesting the comparatively limited clinical usefulness of the peptide antigen in case of chromomycosis.
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  • Effect of Cepharanthin on Production of Active Oxygen by Polymorphonuclear Leukocytes
    Mariko SUZUKI, Shizuo SATO, Michiko TAZAKI, Daisuke SAWAMURA, Kazuo NO ...
    1986 Volume 48 Issue 2 Pages 278-283
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.278
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    To examine the mechanism of beneficial effect of cepharanthin on chronic recurrent aphtha and Behçet’s disease, we investigated its effects in vitro on the production of active oxygen by polymorphonuclear leukocytes (PMN) from five healthy subjects. PMA (phorbol myristate acetate)-induced O2--production, as measured by cytochrome C assay, was inhibited by 83% with 5 μg/ml of cepharanthin and by 98.7% with 10 μg/ml. Luminol dependent chemiluminescence was also inhibited by 29% with 1 μg/ml of cepharanthin, and 95% with 5 μg/ml. On the other hand, an addition of cepharanthin, even in a dose of 50 μg/ml did not abolish the generation of O2- from the xanthine oxidase plus xanthine-xanthine system. The addition of 10 μg/ml cepharanthin had no effect on the viability of the PMN, assayed by the trypan blue exclusion method. These results suggest that cepharanthin may block the cell membrane associated production of active oxygen through a mechanism which differs from the mechanism of action of active oxygen-scavenging drugs such as DDS (4-4-diamino-diphenyl sulphone) and liposome superoxide dismutase.
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  • Histological Studies on Contact Dermatitis III
    Distribution of Fibronectin in Experimental Contact Dermatitis
    Hiroyuki NAGATA, Shojiro NAKAGAWA, Yoji TAKEI, Daisuke OKA, Hiroaki UE ...
    1986 Volume 48 Issue 2 Pages 284-288
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.284
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    The distributions of fibronectin (FN) were investigated in experimental contact dermatitis of guinea pigs induced by 2,4-dinitrochlorobenzene (DNCB), using an indirect immunofluorescent technique with a specific antisera against guinea pig plasma FN. In primary irritant contact dermatitis induced by 5% DNCB, FN was found in the areas corresponding to the cell membrane and cytoplasm of Malpigian cells from 3 to 24 hours after painting. FN was detected on the degenerative epidermis or crusts from 3 to 6 day-lesions. Regenerative epidermis showed no specific immunofluorescence of FN. Similar distributions of FN in epidermis were observed only in 9 hour-lesions of allergic contact dermatitis to DNCB. In the retest reaction, FN was also distributed in the areas corresponding to the cell membrane and cytoplasm of epidermal cells from 5 to 9 hour-lesions and was seen in the upper half of the epidermis in the 24 hour-lesion. The significance of deposits of epidermal FN associated with regeneration of epidermal cells and exclusion of degenerative tissues is discussed.
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  • Observations on the Tissue Fibrinolytic Activity in Donor Site Following Skin Graft in Pigs
    Toshio OHTSUKA
    1986 Volume 48 Issue 2 Pages 289-293
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.289
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    This experiment was carried out in order to investigate the time sequence of tissue fibrinolytic activity at the donor site following skin graft in pigs, using Todd’s technique of fibrinolytic autography. Tissue fibrinolytic activity decreased in the dermis for 6 to 24 hours after obtaining the skin graft, and increased for 3 to 5 days. The return to a pattern of fibrinolytic activity occurred on the 6th to 7th days. Therefore, the increase in fibrinolytic activity may play a role in the development of epidermal regeneration.
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  • Reddish Coloration in the Medium of Slant N and pH Changes
    Hiroe KIRYU, Kazuhiko EGUCHI, Yoshinori SUENAGA
    1986 Volume 48 Issue 2 Pages 294-299
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.294
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    Slant-N is the name of a new variety of DTM (Dermatophyte Test Medium) used to detect dermatophytes. This medium was studied with regard to the relation between the change in pH and the consequent change of the agar from yellow to red.
    1) During growth of the dermatophytes, the medium became alkali. In the case of saprophytes, however, early changes in pH toward acidity preceded changes toward alkalinity.
    2) When the change toward alkalinity reached pH 6.0 or pH 6.1, the color change from yellow to red was observed in all the cultures. The onset of the color change by the dermatophytes tested was always observed earlier than saprophytes. In case of these color changes enabled an early differentiation between the dermatophytes and the saprophytes.
    3) Characteristic differences in the degree of the shifts in pH obtained with different species were classified into three types.
    4) It was considered that the shifts toward alkalinity were produced by alkalinic metabolites from peptone, and the shifts toward acidity were produced by acidic metabolites from glucose in the medium.
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  • Therapeutic Indication for Ingrown Nail
    Mamoru KOHDA, Yoji TAKEI, Yasunori INAGAKI, Hiroaki UEKI
    1986 Volume 48 Issue 2 Pages 300-303
    Published: April 01, 1986
    Released on J-STAGE: March 15, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.48.300
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    Two hundred and thirty-four ingrown toe nails in 130 patients were treated by partial excision. Here the healing ratio was 94.7% while the ratio with conservative treatment was 40.8%. There were frequent recurrences in those treated by nail avulsion only.
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