Abstract
Peptide antigens were newly prepared from the mycelia of Trichophyton, Sporothrix and Fonsecaea species. Tuberculin-type skin test were done at 10 dermatology clinics of university hospital in Japan with these antigens, and also with the conventional test antigens, on clinical cases and their clinical usefulness was evaluated.
1) Peptide antigens from Trichophyton mentagrophytes and T. rubrum gave a positive reaction in 75% of Tinea cases. Specific difference was not proved between these two species.
2) The conventional trichophytin gave considerable fewer positive reaction (25%).
3) Intensity of the reactions were greatly different among each case of tinea.
4) Immediate-type reactions were observed in 85% of the tinea cases.
5) Intensity of the reaction in Kerion Celsi was almost similar to that of the superficial tineas.
6) In the tineas due to Microsporum canis, the most intense reaction was noted with M. canis antigen. However, other antigens (T. mentagrophytes and T. rubrum) also gave a positive reaction.
7) In sporotrichosis, the peptide antigen and the conventional sporotrichin gave almost similar reactions, although several weak responders were noted with the conventional sporotrichin.
8) Immediate-type skin reaction was also observed in sporotrichosis.
9) In 5 case of chromomycosis, 3 gave negative and 2 gave weakly positive reaction, suggesting the comparatively limited clinical usefulness of the peptide antigen in case of chromomycosis.
