A Case of Acute Generalized Exanthematous Pustulosis in a Puerpera

Abstract

We report a 27-year-old woman with acute generalized exanthematous pustulosis. Following the birth of her second child, she exhibited generalized erythematous pustular eruptions on her trunk and intertriginous areas of the limbs with a high fever after receiving minocycline and tiaramide for a perineal laceration. Her white blood cell count was elevated at 11,200/mm³ with 86.5% neutrophils on admission. The biopsy specimens of the erythematous pustular lesions showed a subcorneal abscess with spongiform of Kogoj and mild irregular acanthosis. In the superficial dermis, a mild perivascular infiltration of lymphocytes and neutrophils was mixed with a small number of eosinophils. Both a patch test and the drug lymphocyte stimulation tests with minocycline and tiaramide were negative. No peroral challenge tests were performed.