2003 Volume 65 Issue 2 Pages 134-137
We herein report three cases of localized multiple neurofibromas; Case 1 was a 65-year-old woman with soft light brown nodules localized on the right side of her forehead. Case 2 was a 75-year-old man with soft light brown nodules on two different sites. One site was the right nape while and the other was in the right lower back region. Case 3 was a 51-year-old woman who presented with soft normal colored nodules on her occipital region and right submandibular region. In all cases, the nodules were limited to the previously described body regions. No cases had cafe-au-lait macules or fleckling on their lesions, nor on any parts of their bodies. In all cases, the family history was negative for any similar skin disease, and histopathological examinations revealed those soft nodules to be neurofibromas. In addition, osteomas were found close to the masses of neurofibroma in Case 1. This disorder has been suggested to possibly be a variant of neurofibromatosis. Though there are no reports of gene abnormality of localized multiple neurofibromas, in the future NF1 gene abnormality might be shown to be associated with localized multiple neurofibroma. As a result condition is considered to be an instance of mosaicism of neurofibromatosis (NF 1).
