Abstract
A 64-year-old man, who had a history of pollinosis in the spring season, was referred to our clinic for evaluating the cause of anaphylaxis occurred after drinking soy-milk. His symptoms was ocular itching, cough, nasal congestion, and hives as well as the sensation of airway obstruction. The CAP-FEIA was negative for soybean, but positive for alder pollen and rGly m4. Skin prick test revealed positive reaction to soy and soy-milk, thus soy-milk allergy was diagnosed. Then we performed the basophil activation test based on CD203c with his consumed soy-milk. The CD203c on basophil surface was up-regulated in response to serially diluted soy-milk. From these results, soy-milk allergy was considered to be elicited by Gly m4 which was cross-reacted with alder pollen. This case suggests that the CD203c-based basophil activation test may be useful in the diagnosis of soy-milk allergy.
