Induction of Muscle Hypertrophy in Rats through Low Intensity Eccentric Contraction

Abstract

[Purpose] The purpose of this study was to examine whether a low intensity exercise using an eccentric contraction would result in skeletal muscle hypertrophy in rats. [Subjects and Methods] Eighteen female Wistar rats were used in this study. The rats were randomly divided into three groups. The control group performed no exercise. The level group ran on a treadmill on a 0° incline. The downhill group ran on a treadmill on a −16° incline. The two exercise groups ran on a treadmill at 16 m/min for 90 minutes, once every three days for a total of twenty sessions. [Results] The muscle wet weights, the relative weight ratios, and the muscle fiber cross-section minor axes of the downhill group were significantly larger than those of the control and level groups. There were no differences in the muscle wet weights, the relative weight ratios, and the muscle fiber cross-section minor axes between the control group and the level group. [Conclusion] The stimulation from the low intensity eccentric contraction may have produced enough mechanical stress to induce muscle hypertrophy without the over-stressing that might have produced muscle fiber damage. These results indicate that this technique may be an effective method of inducing hypertrophy in skeletal muscle.