Pathogens in patients with traumatic orthopaedic infection were analyzed microbiologically. The patients consisted of 37 males and 5 females, age ranging from 16 to 85 years (mean age of 40.6). 112 total species of pathogen were identified. Compared with pathogens from other orthopaedic diseases, methicillin-resistant staphylococcus aureus and coagulase negative staphylococci were additionally isolated from patients of traumatic infection. A great number of Staphylococcus spp were isolated from patients with closed fractures. On the other hand, gram negative rod and clostridium groups were mainly isolated from patients with open fractures. Deepness of soft tissue injury and contamination of wound with trauma should be considered in determining the exact antibiotics to be used.