実験的骨減少症ラットに対する組織学的検討

抄録

We investigated bone mass, tibial bone tissue, and urinary deoxypyridinoline (Dpd), as markers of bone metabolism in experimental osteopenia model (ovariectomized) rats. Decreased bone mass in all rats showed significant positive correlation with increased urinary Dpd. Moreover continuity of trabecular bone was lost in the ovariectomied rats. The findings suggest that the markers of bone metabolism can be utilized for selection of treatment, and/or evaluation of the treatment, and possibly decision-making concerning the start treatment.