2003 年 52 巻 1 号 p. 90-92
The purpose of these studies is to clarify the safety and effectiveness of antibiotics-impaired calcium phosphate cement. We measured amikacin density in the following cases: (1) In the saline preserving amikacin-impaired calcium phosphate cement; and (2) In the serum and drained blood in clinical use of amikacin-impaired calcium phosphate cement. The results are following: (1) Effective amikacin density continued for 7 days in the saline; and (2) Amikacin density is quite low in serum. For drained blood, effective amikacin density continued for 2 days. Consequently, amikacin-impaired calcium phosphate cement is safe effective for clinical use.