We report two cases of intramuscular myxoma occurring in the thigh. Case 1 was a 71-year-old man who presented a painless lump in the anterior aspect of the left thigh, which he noticed four months earlier. Physical examination revealed a painless and movable, 1.5×1 cm well demarcated mass in the region of the rectus femoris muscle. MRI showed an oval mass lesion in the muscle. Case 2 was a 63-year-old woman who noticed a painless lump in the lateral aspect of the left thigh. One month earlier. Physical examination revealed a painless and movable, 4×2 cm well demarcated mass in the rectus femoris muscle. MRI showed the mass to be in the vastus lateralis muscle. Final diagnoses were made by histological examination. These cases had a tendency of muscle invasion on MRI and histological examination, which is thought to be a hallmark of diagnosis.
