麻痺領域の一次縫合創の創傷治癒に関する組織化学的考察

抄録

It has been experienced clinically that the scar of primary surgical suture in paralytic area in patient with leprosy or spinal cord injury does not develop hypertrophic scar or keloid formation.
Observation was carried out clinically for the scar of primary surgical suture and was concluded that these surgical procedure which would give rise to neurotic paralysis or hypoesthesia around the incised skin region, was one of the factor which suppressed the enlargement of scar in cosmetic view.
The investigation was carried out in young adult rabbites. One side of brachial plexus of each animals was cut, resulting paralysis and forearmes were wounded bilaterally, exposing subcutaneous tissue, then produced primary sutures. Each pair of woundes were removed together at intervals from 1 hour to 15 days, and were examined histochemically, using alkaline and acid phosphatase, phosphorylase and PAS reactions.
It was revealed that primary wound healing in denerved side was more retardated than in controlled healthy side both in epithelium and corium.