In spite of administration of Vitamin D and/or inorganic phosphate, satisfactory result has not been obtained for treatment of famillial hypophosphatemia.
Two cases were treated with 1α-OH-D3 and inorganic phosphate in our clinic, but hypophosphatemia were residual after the improvement of the metaphyseal roentgenographic findings.
In the first case, the administration of 1α-OH-D3 9, μg/day and phosphate 4.2g/day raised the serum inorganic phosphorus level to 4.6mg/dl.
In the second, 6μg/day and 2.8g/day did it to normal range. Administration of 1α-OH-D3 was considered to activate the intestinal absorption of phosphate.