脊椎・脊髄疾患の髄液免疫グロブリンについて

抄録

Using the method of turbidometric immunoassay, CSF immunoglobulins (IgG, IgA and IgM) were analyzed in 15 samples from normal control subjects and patients with orthopedic neurological diseases, including cervical myelopaty (25), thoracic myelopathy (4) and lumbar radiculopathy.
Mean values of IgG and IgG% (IgG/CSF-total protein x 100) in cases with myelographically proven cervical myelopathy and lumbar radiculopathy were significantly larger than those in control group.
In cervical myelopathy IgG% was significantly elevated with neurological severity, but IgG was not correlated.
Elevated IgG, IgG%, IgM and IgM% were shown in 3 cases of cervical myelopathy. These findings were similiar to those obtained for demyelinating disease. As the origin of the increase, the influence of local immunoglobulin synthesis was suspected.
Thus, for the diagnosis of orthopedic neurological disease which shows unknown etiology and severe neurological status, it is suggested that the quantitation of CSF immunoglobulins is useful.