Breathing oxygen under high pressure increases the concentration of oxygen in the blood and improves hypoxia situation. So HBO is applied to many diseases. In orthopaedics HBO is used in gas gangrene known to be anaerobic infection. We utilized HBO in soft tissue infection (including aerobic infections) adjunctive to surgical treatment and antibiotics therapy. The results were good. If gas formation is found in the wound, HBO should be done as soon as possible. However, in the cases of aerobic soft tissue infections, main therapy is surgical treatment with antibiotics therapy, and HBO is adjunctive therapy.