細菌の生体材料への付着

血漿の影響について

抄録

In vitro, disks of serum coated or serum uncoated biomaterials were exposed to the slime producing Staphylococcus to study the effects of serum on bacterial attachment to biomaterials. Direct scanning electron microscopic observation showed that fibrous strands interconnected the adherent bacteria and extensive background matrix enclosed bacterial colonies. This adherent mode of growth may reduce the susceptibility of bacteria to host clearance mechanisms and antibiotic therapy and thus may be a fundamental factor in biomaterial induced infection.
We have tested the ability of bacteria to adhere to serum coated or serum uncoated PMMA and SUS 316L. Adherence assays revealed that bacterial adherence to serum coated PMMA was about two folds higher than serum uncoated PMMA. Bacterial adherence to serum uncoated SUS 316L was almost same as serum coated SUS 316L. These results suggest that serum has an effect on the bacterial adherence to PMMA, but no effect on the bacterial adherence to SUS 316L.