Twenty-four cases of monoarticular joint disease were diagnosed as non-classified monoarthritis at our hospital. These patients underwent labolatory examinations and open biopsy, and were followed from 1 month to 6 years and 7 months (mean, 1 Year and 11 months). Four patients were diagnosed as having rheumatoid arthritis, 2 in infectious arthritis, 1 in tuberculous arthritis and 1 with localized nodular synovitis. The remaining patients' diagnosis was non-specific arthritis.