末梢神経急性圧迫損傷に対する薬物療法の有効性に関する実験的研究

第三報: 神経外膜とステロイドの有効性について

抄録

Experiments in our laboratory have shown that steroid therapy commenced immediately before the operation prevents the functional deficit caused by silicone cuffs applied to intact sciatic nerves in rats. A further study showed that epineurectomy alone caused no significant functional deficit. In this experiments when compression was applied after removal of the epineurium the same dose of steroid used in our previous experiments proved unable to prevent the functional deficit.
In intact nerves, it is probable that the trauma of cuff application caused edema of the intraneural pressure in the segment under the cuff and thus neuronal injury. The maximum injury and edema would occur in the epineurium, which can be prevented by steroid administration. Following epineurectomy edema of the perineurium and endoneurium resulted in a similar pressure increase that was not prevented by the steroids.