Association with urethritis, which is caused by several microorganisms including gonococcus, is recently thought to be important for a diagnosis of Reiter's syndrome, although the syndrome has been classically described as the combination of nongonococcal urethritis, arthritis and conjunctivitis. A 35-year-old man was affected by gonococcal urethritis two weeks before his complaint of lrft knee and right second toe pain. He had also balantitis, mucous membrane erosion, heel pain and weight loss. Moreover, HLA-B 27 was positive in his blood cell, and no bacteriae was detected in the blood or synovial fluid. According to the symptoms and findings, Reiter's syndrome was mostly suspected for this case. The diagnosis of this syndrome is difficult since history of bacterial urethritis is apt to miss to hear from patients with arthritis. Careful history taking seemed to be significant for the accurate diagnosis.
